{"product_id":"abm156750","title":"TAL1\/2 (Acetyl Lys221\/Acetyl Lys222\/Acetyl Lys36\/Acetyl Lys37) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ealternative products:The splicing pattern is cell-lineage dependent|disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.|The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.|Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.|PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.|PTM:Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122| ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells| since it could not be observed in large vessel endothelial cells.|Contains 1 basic helix-loop-helix (bHLH) domain.|subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3| LDB1| TAL1 and TCF3.|tissue specificity:Leukemic stem cell.|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659848098132,"sku":"ABM156750","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659848130900,"sku":"ABM156751","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659848163668,"sku":"ABM156752","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ce80d8780d2e9c209efb97aea85182596f04f2b6a6fe9b471422f3e0046e0da3.jpg?v=1792157388","url":"https:\/\/www.abmium.com\/de\/products\/abm156750","provider":"ABMIUM","version":"1.0","type":"link"}