{"product_id":"abm154173","title":"Bag-3 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eBAG proteins compete with Hip for binding to the Hsc70\/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660708159828,"sku":"ABM154173","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660708192596,"sku":"ABM154174","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660708225364,"sku":"ABM154175","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-c096200164a4265e932e1991a33cef0a27a62cf339db7c792273dc3b2f26f941.jpg?v=1792157364","url":"https:\/\/www.abmium.com\/de\/products\/abm154173","provider":"ABMIUM","version":"1.0","type":"link"}