{"product_id":"abm154047","title":"GluR-2(Phospho Ser880) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG-\u0026gt;CGG; Q-\u0026gt;R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q\/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants enco\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57660663136596,"sku":"ABM154047","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660663169364,"sku":"ABM154048","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57660663202132,"sku":"ABM154049","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-bd1d930a9aa9d68abc068137bf0ee11ba6c178d900d410b7d1abb00c47fe9711.jpg?v=1792157347","url":"https:\/\/www.abmium.com\/de\/products\/abm154047","provider":"ABMIUM","version":"1.0","type":"link"}