{"product_id":"abm153243","title":"Apaf-1-ALT Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eAPAF1 encodes a cytoplasmic protein that initiates apoptosis. This protein (apoptotic peptidase activating factor 1) contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659943813460,"sku":"ABM153243","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659943846228,"sku":"ABM153244","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659943878996,"sku":"ABM153245","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-7dd076c3e2eb37b611e44bda7aeda032bb79b0da36eac1faf8fde4a66ab1ff28.jpg?v=1792157357","url":"https:\/\/www.abmium.com\/de\/products\/abm153243","provider":"ABMIUM","version":"1.0","type":"link"}