{"product_id":"abm152412","title":"Actinin-Alpha1\/2\/3\/4 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eAlpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. ACTN1 encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for ACTN1.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660303966548,"sku":"ABM152412","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660303999316,"sku":"ABM152413","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660304032084,"sku":"ABM152414","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-e129f2c577f6f433d17b55eaccf59bceae0cb774f85b592e98a5f628c6a517a1.jpg?v=1792157332","url":"https:\/\/www.abmium.com\/de\/products\/abm152412","provider":"ABMIUM","version":"1.0","type":"link"}