{"product_id":"human-tgfbr3-tgf-beta-riii-picokine-quick-elisa-kit-fek1383","title":"Human TGFBR3\/Tgf Beta Riii PicoKine® Quick ELISA Kit","description":"\u003cp\u003eHuman TGFBR3\/Tgf Beta Riii PicoKine® Quick ELISA Kit is a research-use ELISA kit from Boster Bio for measuring Transforming growth factor beta receptor type 3 in Cell culture supernatant, Cell lysates, serum and plasma (heparin, EDTA). samples from Human. Use the listed assay range, sample guidance and protocol documents to assess suitability for the intended study.\u003c\/p\u003e\nHuman TGFBR3\/Tgf Beta Riii PicoKine® Quick ELISA Kit (120 minutes, 96 Tests). Quantitate Human TGFBR3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg\/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.\u003cp\u003eBetaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell- surfacechondroitin sulfate \/ heparan sulfate proteoglycan \u0026gt;300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved ly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors. By cDNA array and immunohistochemistry analyses, it is found that TGFBR3 expression is lost in most breast cancers examined in association with loss of heterozygosity of the TGFBR3 locus. TGFBR3 expression decreased during breast cancer progression, and low levels predicted decreased recurrence-free survival in patients. Loss of TGFBR3 through allelic imbalance is a frequent genetic event during breast cancer development that increases metastatic potential. Also, TGFBR3 can localize transformation in the heart and play an essential, nonredundant role in TGF-beta signaling.\u003c\/p\u003e\u003ch3\u003eProduct information\u003c\/h3\u003e","brand":"Boster Bio","offers":[{"title":"96 wells\/kit, with removable strips.","offer_id":56042556752212,"sku":"ABM32171","price":442.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ek1383_1.png?v=1781659285","url":"https:\/\/www.abmium.com\/cy\/products\/human-tgfbr3-tgf-beta-riii-picokine-quick-elisa-kit-fek1383","provider":"ABMIUM","version":"1.0","type":"link"}