ABMIUM target intelligence
aurora kinase B
AURKB encodes Aurora kinase B, a serine/threonine kinase component of the chromosomal passenger complex and a major regulator of mitosis and cytokinesis. This target record connects reviewed human AURKB identifiers with ABMIUM catalogue products targeting Aurora B/AURKB.
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Names used across publications, databases and supplier catalogues.
AURKB is a serine/threonine kinase within the chromosomal passenger complex. It regulates chromosome alignment and segregation, kinetochore-microtubule attachment, spindle organisation and the onset and completion of cytokinesis. AURKB phosphorylates chromosomal-passenger-complex components and multiple mitotic substrates, and participates in the abscission checkpoint that prevents premature cytokinetic separation when chromosome bridges persist.
AURKB is widely studied in mitosis, chromosome segregation, kinetochore signalling, spindle function, cytokinesis and proliferative disease models. Because Aurora-family kinases share structural similarity, reagent selection should consider isoform specificity, phosphorylation state, cell-cycle stage, species, application and product-level validation.