ABMIUM target intelligence
ATM serine/threonine kinase
ATM (ATM serine/threonine kinase), also known as serine-protein kinase ATM and A-T mutated, is a central DNA-damage-response kinase activated by DNA double-strand breaks. It coordinates checkpoint signaling and genome-stability responses while ABMIUM products below provide catalogue-backed reagents for ATM research.
Read full target overviewABMIUM research catalogue
Loading products for ATM…
Names used across publications, databases and supplier catalogues.
ATM is a large serine/threonine protein kinase that functions as a DNA damage sensor and signaling hub. Following DNA double-strand breaks and other genotoxic stresses, ATM phosphorylates downstream checkpoint and repair factors to coordinate cell-cycle control, DNA repair, chromatin responses and stress signaling.
ATM is studied in DNA double-strand-break signaling, checkpoint activation, genome stability, radiosensitivity, oxidative and genotoxic stress, and DNA-repair pathway experiments. Results can depend on damage stimulus, phosphorylation state, time point, cell-cycle context and assay format, so product-level validation should be matched to the experimental question.