ABMIUM target intelligence
apoptotic peptidase activating factor 1
APAF1 (apoptotic peptidase activating factor 1; Apaf-1) is a core scaffold of the intrinsic apoptosis pathway. Following mitochondrial cytochrome c release, APAF1 assembles the apoptosome and recruits procaspase-9, linking mitochondrial stress to downstream caspase activation.
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Names used across publications, databases and supplier catalogues.
APAF1 binds cytochrome c and ATP or dATP, then oligomerizes into the apoptosome. Through its CARD domain, the complex recruits and activates procaspase-9, which initiates downstream executioner-caspase signalling including caspase-3 activation.
APAF1 is studied in mitochondrial apoptosis, apoptosome assembly, caspase activation and cell-death responses to cellular stress. Use ABMIUM catalogue products to investigate APAF1/Apaf-1 in an appropriate experimental system, confirming species, sample type, application and product-level validation before use.