ABMIUM target intelligence
AKT serine/threonine kinase 3
AKT3 encodes AKT serine/threonine kinase 3, whose reviewed human protein is RAC-gamma serine/threonine-protein kinase (protein kinase B gamma/PKB gamma). It is one of the three AKT kinases that couple growth-factor signalling to phosphorylation programmes controlling cell survival, growth, metabolism and proliferation.
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Names used across publications, databases and supplier catalogues.
AKT3 is a serine/threonine kinase activated within PI3K-AKT signalling. Reviewed UniProt describes AKT3 as phosphorylating downstream substrates that regulate metabolism, proliferation, survival, growth and angiogenesis. Compared with AKT1 and AKT2, AKT3 is less extensively characterised and has particularly important roles in brain development.
AKT3 is studied in PI3K-AKT pathway biology, kinase signalling, neural development and isoform-specific AKT regulation. When comparing ABMIUM AKT3 reagents, match species, assay format, application and product-level validation to the experimental question.